The 2021 NHL Entry Draft was held on Friday, July 23, 2021 (1st round) and Saturday, July 24, 2021 (2nd to 7th rounds) via video conference call at the NHL Network studios in Secaucus, New Jersey. The Buffalo Sabres won the draft lottery with the Seattle Kraken and Anaheim Ducks winning the second and third picks, respectively. The Sabres selected Owen Power from the University of Michigan of the NCAA with the first overall pick.
The Pittsburgh Penguins would draft 25th overall out of 32 teams in each round after finishing the 2020-21 regular season with 77 points, winning the MassMutual East Division, and had 39 wins overall.
The Pittsburgh Penguins would draft 25th overall out of 32 teams in each round after finishing the 2020-21 regular season with 77 points, winning the MassMutual East Division, and had 39 wins overall.
2022 Pittsburgh Penguins NHL Entry Draft Selections
| Choice | Round | Pick | Overall | Player | Position | 2020-21 Amateur Club |
| 1 | 2 | 26 | 58 | Tristan Broz | C | Fargo Force (USHL) |
| 2 | 5 | 26 | 154 | Isaac Belliveau | D | Gatineau Olympiques (QMJHL) |
| 3 | 7 | 2 | 194 | Ryan McCleary | D | Portland Winterhawks (WHL) |
| 4 | 7 | 23 | 215 | Daniel Laatsch | D | Sioux City Musketeers (USHL) |
| 5 | 7 | 26 | 218 | Kirill Tankov | C | SKA Varyagi (MHL) |
Tristan Broz |
Isaac Belliveau |
Ryan McCleary |
Daniel Laatsch |
Kirill Tankov |
Pittsburgh's original first round choice (26th overall)
Pittsburgh selected center Tristan Broz from Fargo (USHL) in the second round with the 58th overall choice in the 2021 NHL Entry Draft.
The Penguins' original third round choice (90th overall)
Pittsburgh's original fourth round choice (122th overall)
The Penguins selected defenseman Isaac Belliveau from Gatineau (QMJHL) in the fifth round with the 154th overall choice in the 2021 NHL Entry Draft.
Pittsburgh's original sixth round choice (186th overall)
As a result of a trade on October 25, 2019 that sent Erik Gudbranson to the Anaheim Ducks in exchange for Andreas Martinsen and Anaheim's seventh round choice (194th overall) in the 2021 NHL Entry Draft. With the seventh round choice (194th overall) acquired from Anaheim, the Penguins selected defenseman Ryan McCleary from Portland (WHL).
On October 7, 2020, Pittsburgh acquired a seventh round choice (215th overall) from Washington in exchange for the Penguins seventh round choice (211th overall) in the 2020 NHL Entry Draft. With the seventh round choice (215th overall) acquired from Washington, the Penguins selected defenseman Daniel Laatsch from Sioux City (USHL).
The Penguins selected center Kirill Tankov from SKA Varyagi (MHL) with the 218th overall choice in the 2021 NHL Entry Draft.
Pittsburgh selected center Tristan Broz from Fargo (USHL) in the second round with the 58th overall choice in the 2021 NHL Entry Draft.
The Penguins' original third round choice (90th overall)
Pittsburgh's original fourth round choice (122th overall)
The Penguins selected defenseman Isaac Belliveau from Gatineau (QMJHL) in the fifth round with the 154th overall choice in the 2021 NHL Entry Draft.
Pittsburgh's original sixth round choice (186th overall)
As a result of a trade on October 25, 2019 that sent Erik Gudbranson to the Anaheim Ducks in exchange for Andreas Martinsen and Anaheim's seventh round choice (194th overall) in the 2021 NHL Entry Draft. With the seventh round choice (194th overall) acquired from Anaheim, the Penguins selected defenseman Ryan McCleary from Portland (WHL).
On October 7, 2020, Pittsburgh acquired a seventh round choice (215th overall) from Washington in exchange for the Penguins seventh round choice (211th overall) in the 2020 NHL Entry Draft. With the seventh round choice (215th overall) acquired from Washington, the Penguins selected defenseman Daniel Laatsch from Sioux City (USHL).
The Penguins selected center Kirill Tankov from SKA Varyagi (MHL) with the 218th overall choice in the 2021 NHL Entry Draft.