The 2010 NHL Entry Draft was held on Friday, June 25, 2017 (1st round) and Saturday, June 26, 2010 (2nd to 7th rounds) at the Staples Center, home of the Los Angeles Kings. The Edmonton Oilers won the draft lottery with Toronto and Florida winning the second and third picks, respectively. Edmonton selected left wing Taylor Hall from Windsor (OHL) with the first overall pick.
The Pittsburgh Penguins, who finished the 2009-10 season with 101 points (47-28-7) and lost to the Montreal Canadiens in the second round of the 2010 Stanley Cup Playoffs, would draft 20th overall out of 30 teams in each round.
The Pittsburgh Penguins, who finished the 2009-10 season with 101 points (47-28-7) and lost to the Montreal Canadiens in the second round of the 2010 Stanley Cup Playoffs, would draft 20th overall out of 30 teams in each round.
2010 Pittsburgh Penguins NHL Entry Draft Selections
| Choice | Round | Pick | Overall | Player | Position | 2009-10 Amateur Club |
| 1 | 1 | 20 | 20 | Beau Bennett | RW | Penticton Vees (BCHL) |
| 2 | 3 | 20 | 80 | Bryan Rust | RW | USA U-18 (USHL) |
| 3 | 4 | 20 | 110 | Tom Kuhnhackl | RW | Landhsut Cannibals (German 2nd Bundesliga) |
| 4 | 5 | 20 | 140 | Kenny Agostino | LW | Delbarton School (USHS-NJ) |
| 5 | 6 | 2 | 152 | Joe Rogalski | D | Sarnia Sting (OHL) |
| 6 | 6 | 20 | 170 | Reid McNeill | D | London Knights (OHL) |
Beau Bennett |
Bryan Rust |
Tom Kuhnhackl |
Kenny Agostino |
Joe Rogalski |
Reid McNeill |